Tuesday, June 2, 2015

A computational modelling approach for deriving biomarkers to predict cancer risk in premalignant disease

A computational modelling approach for deriving biomarkers to predict cancer risk in premalignant disease

, ,

Abstract

The lack of effective biomarkers for predicting cancer risk in premalignant disease is a major clinical problem. There is a near-limitless list of candidate biomarkers and it remains unclear how best to sample the tissue in space and time. Practical constraints mean that only a few of these candidate biomarker strategies can be evaluated empirically and there is no framework to determine which of the plethora of possibilities is the most promising. Here we have sought to solve this problem by developing a theoretical platform for in silico biomarker development. We construct a simple computational model of carcinogenesis in premalignant disease and use the model to evaluate an extensive list of tissue sampling strategies and different molecular measures of these samples. Our model predicts that: (i) taking more biopsies improves prognostication, but with diminishing returns for each additional biopsy; (ii) longitudinally-collected biopsies provide only marginally more prognostic information than a single biopsy collected at the latest possible time-point; (iii) measurements of clonal diversity are more prognostic than measurements of the presence or absence of a particular abnormality and are particularly robust to confounding by tissue sampling; and (iv) the spatial pattern of clonal expansions is a particularly prognostic measure. This study demonstrates how the use of a mechanistic framework provided by computational modelling can diminish empirical constraints on biomarker development.

1 comment:

  1. I was diagnosed with stage 3 breast cancer in August 2010. A valuable friend told me about Dr. Itua Herbal Center in West Africa. She gave me her phone number and email address. I quickly contacted him to guarantee that his herbal medicines will heal my cancer and I will heal forever I said OK.I ask him what is the healing process, he asks me to pay the fees I did and within 7 working days he sent me the herbal medicine and then he asked me I told my friend Gomez about the herbal drug so that he gave me to go and drink it.So after drinking for two weeks, I was cured, I am so grateful and I promise that I will do it I recommend to anyone who has cancer and that that I am doing. Herbal medicine Dr. Itua makes me believe that there is hope for people with Parkinson's disease, schizophrenia, scoliosis, bladder cancer, colorectal cancer, breast cancer, kidney cancer. , Leukemia, lung cancer, skin cancer, uterine cancer, prostate cancer Fibromyalgia,
    Fibrodysplasia Syndrome, Epilepsy,Sclerosis sickness, Dupuytren's Disease, Diabetes, Celiac Disease, Angiopathy, Ataxia, Arthritis, Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Lupus, Adrenocortic Carcinoma.Asthma, Allergic Diseases.HIV Help, Bladder cancer,Brain cancer,Esophageal cancer,Gallbladder cancer,Gestational trophoblastic disease,Head and neck cancer,Hodgkin lymphoma
    Intestinal cancer,Liver cancer,Melanoma,Mesothelioma,Multiple myeloma,Neuroendocrine tumors
    Non-Hodgkin lymphoma,Cervical Cancer,Oral cancer,Ovarian cancer,Sinus cancer,Soft tissue sarcoma,Spinal cancer,Stomach cancer
    ,Testicular cancer,Throat cancer,Meniere's disease,Thyroid Cancer,Vaginal cancer,Vulvar cancer
    HIV Aids, Herpes, Disease Chronic inflammatory, Memory disorder,
     Here is his contact information ...... [Email ... drituaherbalcenter@gmail.com. Whatsapp ... + 2348149277967]

    ReplyDelete